In 1963, the Lake County School Board (LCSB) requested approval from the Florida Department of Education to build a vocational center. In the fall of 1965, state and federal construction funds were received under the Vocational Education Act of 1963. While waiting for a facility to be built, Cosmetology, Auto Mechanics, and Business Education programs began in the fall of 1966 in Leesburg, Florida.

In July 1968, the main campus construction was completed on the present 37½-acre site. Construction for the Institute of Public Safety (IPS) extension campus began in 1992 and was completed in 1994. IPS is located on two separate properties and includes state-of-the-art firing and driving ranges as well as classroom facilities for Firefighting, Law Enforcement, and Corrections programs. Lake Technical College’s campuses have grown to encompass 231,548 square feet.

In 2016, Lake Technical College entered into a partnership with Lake Sumter State College (LSSC) and began offering Practical Nursing, Nursing Assistant, Paramedic, GED and ESOL programs on the LSSC South Lake and Sumter campuses.

In the Fall of 2017, Lake Technical College opened the Center for Advanced Manufacturing to meet the growing need to prepare skilled technicians in CNC machining, welding, fabrication and other manufacturing careers.